Could not the translation for "You lose" be "Vous perde" as well as "Vous perdez"?
No. < Vous perdez > is the only correct conjugation for vous with perdre in the present tense of the indicative mood.
You may be confusing the situation of < vous > being used in the singular polite form in compound tenses, in which case past participle agreement of number and gender can occur in specific situations.
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