Je n’ai guère d'amis

Hi Sumesh, 

No, you can't say des amis because of the negative ne...guère which works as ne ....pas, ne...plus, etc.

Take a look at the following Kwiziq lesson if you have forgotten that rule -

https://progress.lawlessfrench.com/revision/grammar/the-partitive-article-in-negative-sentences

Hope this helps!