Look at these questions:
Note that a way to ask ''What....?'' in French is to use the expression Qu'est-ce que...? followed by your statement in the normal order.
Notice also that you use qu'est-ce que if it appears at the start but quoi at the end.
To simply ask "What?" on its own, using "Quoi ?", though correct, is actually considered a bit abrupt and rude. Instead, we'll consider more polite to use "Comment ?":
While qu'est-ce que means ''what ...'', est-ce que introduces a YES or NO question (is it that...).
Que can be used at the start, but the statement will then be inverted (it's a more formal way of asking questions).