Note first that "en" is never used to replace people. As for things, it depends on whether the original phrase it refers to is introduced by the preposition "de":E.g. Tu veux de l'eau ? Tu en veux ?E.g. Je me moque de ton pull. Je m'en moque.
Here are links to the lessons explaining when to use "en":
I hope that's helpful!
A bientôt !
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